Why TRACE-AF?

Sudden/unexplained death or cardiac arrest occurred in ~1 in 5,000 patients after atrial fibrillation ablation in the MANIFEST-US registry. Studying these rare events will require learning from the patient, clinical and procedural characteristics of the rare patients who suffer these early unexplained deaths.

TRACE-AF will be a retrospective patient-level registry of all patients who suffered sudden/unexplained death, generalized coronary vasospasm or malignant arrhythmia early after catheter ablation for atrial fibrillation or related arrhythmias.

Side-by-side bar charts comparing causes of death from MANIFEST-US and MAUDE databases. MANIFEST-US shows cardiac arrest and sudden death as top causes. MAUDE lists insufficient information and cardiac arrest/VT as leading causes.
Scatter plot chart titled 'Timings of Deaths After Pulsed Field Ablation' comparing two cohorts, MANIFEST-US and MAUDE Database. The x-axis shows days from 0 to 30, and the y-axis indicates cohort groups. Data points represent different types of death events with symbols: squares for sudden death or cardiac arrest, triangles for death with explanation or procedure-related death, and circles for insufficient information. The chart displays the timing and frequency of death types post-procedure.

*MANIFEST-US. J Am Coll Cardiol. 2026; 87 (2): 172-193. PMID: 41389071